RENOVO NEURAL

Renovo is a designer CRO that brings state-or-the art technologies to investigate therapeutic enhancement of remyelinating therapies in rodent models of multiple sclerosis. They have over 5 years of experience in offering the rodent model of cuprizone induced demyelination to Big Pharma, Biotech and academic institutions. This experience provides a valuable data base of outcome measures which includes thousands of mice at each time point. They have an accurate indication of the baseline for demy... elination and the rate of spontaneous remyelination. We have documented that endogenous remyelination can be enhanced by therapeutic approaches that are documented by robust primary outcomes. Several aspects of our protocol distinguish our model from others. During cuprizone-mediated demyelination, we inhibit spontaneous remyelination with daily injections of rapamycin. This provides a baseline of near total demyelination at the beginning of therapeutic treatment. Without rapamycin treatment it is impossible to detect a therapeutic effect. The following outline will provide additional insight to the unique nature of the Renovo Augmented Cuprizone Model and why it is superior to conventional cuprizone-only studies.More